https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20558 Wed 11 Apr 2018 17:17:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12674 Wed 11 Apr 2018 09:57:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11887 Wed 11 Apr 2018 09:38:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26567 TM GX Human Inflammation Kit 2. Results: Following the interventions, clinical characteristics and plasma IL-6 and CRP were unchanged. Sputum neutrophil proportion and absolute count was increased and macrophage proportion decreased by rosuvastatin (P = 0.020 and P = 0.015; respectively). Rosuvastatin increased LTB4R and decreased CXCL10 and AGER gene expression in white blood cells. The addition of lycopene and omega-3 fatty acids decreased LTB4R and increased CXCL10 to basal levels, whilst combined use of interventions increased ALOX15 blood gene expression. Conclusion This study shows that rosuvastatin, omega-3 fatty acids and lycopene have some anti-inflammatory effects systemically, but rosuvastatin may increase airway neutrophils, which would be undesirable in COPD patients, warranting further investigation.]]> Wed 02 Mar 2022 14:27:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54277 Thu 15 Feb 2024 14:39:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7396 Sat 24 Mar 2018 08:42:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8243 3.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P=0.05), eicosapentaenoic acid (EPA; P=0.002) and docosapentaenoic acid (DPA; P=0.01). The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk.]]> Sat 24 Mar 2018 08:40:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7613 Sat 24 Mar 2018 08:34:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7109 Sat 24 Mar 2018 08:34:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12427 2.25) children (33%) had an omega-3 index of < 4.0 (high risk) compared with non-obese children (BMI z-score < 2.25) (17%). Simultaneously, the number of children with a higher omega-3 index (6.0–8.0 lower risk) was lower in the obese (13%) versus non-obese children (25%, respectively). A moderate, but statistically significant correlation was found between O3I and fasting insulin level (r = −0.3, P = 0.03) and with homeostatic model assessment (HOMA) scores (r = −0.3, P = 0.04). Conclusion: The observed association between the omega-3 index, weight status and insulin resistance in children highlights the importance of omega-3 fatty acids in the prevention of obesity-related chronic diseases in later life. The results presented merits confirmation in a larger sample of obese children.]]> Sat 24 Mar 2018 08:17:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27804 Sat 24 Mar 2018 07:37:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27246 Sat 24 Mar 2018 07:29:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27755 Sat 24 Mar 2018 07:27:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38396 Mon 29 Jan 2024 17:47:06 AEDT ]]>